Drug Clearance
The most important pharmacokinetic parameter. Determines maintenance dose.
Drug Elimination
Drug clearance and dose
requirements vary markedly throughout life.
Drug Elimination
Volume of Distribution
The volume into which a drug appears to be distributed. Determines loading dose.
Volume of Distribution
Dosing and Age
Drug clearance and dose
requirements vary markedly throughout life.
Dosing and age
The Half-life
The time for the concentration of
the drug to halve.
Half life
Dosing Variations
The route of drug administration influences pharmacokinetics.
Dosing Variations
Oral Availability
The fraction of drug that reaches the
systemic circulation after oral ingestion.
Oral availability
Pharmacodynamics
The action of the drug on the body.
Pharmacodynamics
Saturable Drug Metabolism
When drug concentrations exceed the capacity of metabolism.
Saturable Drug Metabolism
Protein Binding
Only important in interpreting
measured drug concentrations.
Protein Binding
PH and Pharmacokinetics
Acids are ionized in basic media.
Bases are ionized in acidic media.
PH and Pharmacokinetics
Effect of drugs on the pregnancy.
Effect of pregnancy on the drugs.
Drugs in Pregnancy
Drugs in Pregnancy
Drug Interactions
How one drug affects the concentrations or actions of another.
Drug Interactions
Drug Transport
Active transporters can help prevent some drug toxicities and aid uptake of some drugs.
Drug Transport
Pharmacogenetics
How genes determine drug concentrations.
Pharmacogenetics
Graph Plotter
Vary your dose regimen for different clinical settings.
Graph Plotter
Tutorials
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