Pharmacogenetics
Pharmacogenetics
Sometimes people have different drug clearances because their genetics (genotypes) differ.
Each genotype has a phenotype (e.g. enzyme activity) that has its own normal distribution.The different normal distributions are termed polymorphisms.
NB: The 'normal' status is the EM, which is sometimes called the 'wild type'.
Toggle the genetic status buttons to see how that affects drug concentrations.
- wild type allele
- mutant allele
Chromosome
Alleles
Population (%)
Time
Concentration
Min toxic conc
Min effective conc
PM
IM
EM
UM