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Dosing by Injection

The mode of drug administration influences the rate at which effective plasma concentrations are achieved. A loading dose also allows earlier achievement of effective concentrations.

Observe how the drug concentration-time profiles for IV versus oral dosing, with and without loading doses.

Then see how slow release pills allow longer dose intervals. A loading dose can also be used with slow release pills.

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Cp

Time (h)

minimum toxic concentration

minimum effective concentration

CLEARANCE

Give dose in: