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Effects of Drugs on Pregnancy

In the first 4 weeks, prior to implantation, drug exposure is relatively safe as the foetus is not exposed to the mother's blood supply. An adverse effect at this time is likely to result in spontaneous abortion (all or nothing effect).

Post-partum, drugs with a long half-life may continue to affect the baby. Drugs with a short half-life may result in neonatal withdrawal symptoms. After implantation, foetal drug concentrations are similar to those in the mother. Adverse effects depend on both drug toxicity and the developmental stage of the foetus. Adjust slider and observe the major effects.

Sperm Animation Egg Baby

Safe
(preimplantation)

1. TRIMESTER

Teratogenicity

Spontaneous abortion

2. TRIMESTER

General development esp. neurological

3. TRIMESTER

Acceleration or delay of delivery

Haemorrhage (mother & baby)

POSTPARTUM

Drug withdrawal

Prolonged drug activity in baby

Patent ductus arteriosus

1 40