Protein Binding and Clearance
When the amount of binding protein is reduced, (e.g. in liver or renal disease) the free drug concentration is not altered.
Commonly quoted drug concentrations include both bound and free drug i.e. total drug.
When Cl is altered, the ratio of free to bound drug does not change. This can occur in renal or liver disease or with drug interactions.
Adjust P.B. and Cl sliders to visualise these changes.
NB: Dynamic model
10 mg/L Total drug
1 mg/L Free drug
9 mg/L Bound drug